Our Project 2024

In 2024, we revolutionize cancer treatment by using the tumor-associated microbiome as a metaphoric trojan horse! Our project targets tumor-specific bacteria to deliver precision treatment and combat tumor growth.

What?

We're developing a new colorectal cancer treatment that targets bacteria predominantly found within tumors. Our approach delivers potent toxins directly to the tumor site, selectively destroying cancer cells.

Why?

Traditional cancer therapies can be harsh and don't always fully eliminate tumors. Our bacteria-targeting approach aims to provide a more precise, less toxic treatment with improved outcomes for colorectal cancer patients.

How?

We identify bacteria predominant to colorectal tumors and design a fusion protein that binds specifically to them. The enzyme of our fusion protein converts a non-toxic prodrug to a potent cytotoxin. This creates a targeted weapon that selectively destroys cancer cells within the tumor environment.

Learn more about our project here

Corresponding Hardware Project

Motivation

This year’s hardware team is creating a rapid test for hospital labs, commercializing synthetic biology, and personalizing cancer treatment.

Microfluidic Chip

The chip, a microbioreactor the size of a microscope slide, cultivates spheroids of the patient’s tumor. Different cytostatics are tested via microchannels, providing quick results to select an individual therapeutic agent. A device with color sensors records data, while an Arduino evaluates it.

Future Vision

Doctors, especially in developing countries, can rapidly test for personalized cancer therapy. Additionally, a digital patient file will be created, with the chip data anonymously uploaded to a central database to streamline and speed up medication searches.

Corresponding Modeling Project

Motivation

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Microfluidic Chip

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Future Vision

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Support us

Your support empowers our iGEM team to develop our skills and pursue groundbreaking research in cancer treatment. Furthermore, the students acquire soft skills, whereby your support contributes to the development of a new generation of leaders. Help us grow as scientists and people and contribute to advancements in the field.

Our Partners